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What is Alprostadil


Alprostadil suppositories and injections are administered for the treatment of any type of erectile dysfunction any men might have, including but not limited to inability to get and maintain erection and impotence. This remedy belongs to the class of drugs called vasodilators which work by relaxing the blood vessels and muscles of the penis and allowing more blood enter the male organ, thus, promoting a hard and durable erection.

Despite the popular belief, vasodilators don’t increase sexual desire, cure impotence or prevent the spread of STDs.


If you were prescribed Alprostadil as powder, you’ll have to mix it with some liquid (mostly water) according to the instructions given by your healthcare provider or the ones provided on the package. Then it has to be injected into the penis. If the remedy comes in the form of a urethral suppository, it has to be put into the urinary opening.

It is important to use Alprostadil before sexual intercourse. Erection usually occurs 5-20 minutes after the injection and 5-10 minutes after the use of a suppository and lasts for 30-60 minutes. Injections have to be used no more than 3 times a week with a gap of 24 hours between doses. The suppository shouldn’t be administered more than twice during 24 hours. To avoid adverse reactions and get the most out of the remedy, it is necessary to follow the directions of your doctor or carefully read the label and take Alprostadil strictly as directed.

During the course of treatment you might need to either increase or decrease the dose. Don’t do it yourself but turn for medical advice. Inform your doctor whether your erections are satisfactory or they need to last longer. If you have any questions, ask your doctor to explain to you the correct use of Alprostadil.

Precautions and Contraindications

Before starting the therapy with Alprostadil, you have to inform your doctor whether you have an allergy to this drug, other prostaglandins such as bimatoprost, travoprost, misoprostol, latanoprost, etc. Also, inform your healthcare provider about all the other prescription and over-the-counter medicines you are currently using or are planning to take, as well as supplements, vitamins, and herbal remedies. Mention blood thinners, allergy or cold medications, appetite suppressants, drug that treat sinus issues, high blood pressure, other erectile dysfunction medicines.

Inform your doctor if you have ever had such conditions as blood cell problems, multiple myeloma, polycythemia, sickle cell anemia, leukemia, cavernosal fibrosis, Peyronie’s disease, heart failure or penile implant, or the history of lung, kidney, liver disease, bleeding disorder or fainting.

Alprostadil Interactions

Alprostadil may interact with the following medicines: high blood pressure drugs and blood thinners. Inform your doctor about any remedies you are currently using or are planning to use to avoid the risk of side effects.

Side Effects

Among the common side effects that may arise during the therapy and don’t need special attention until they become bothersome and severe are the following: headache, redness of the penis, pain in the penis, perineum, testicles, or legs, burning sensations or warmth in the area of the urinary opening, vision and skin problems, back pain, bleeding in the place where the medicine has been put.

Serious adverse reactions include the following: fainting, fast heartbeat, prolonged erection that lasts more than four hours, nodules on the penis, swelling, redness, unusual curving or tenderness of the erected penis, swollen veins in legs. These need to be reported to your healthcare provider immediately.

Alprostadil and Other Drugs

Inform your doctor about all the medications you are currently taking mentioning other drugs, herbal remedies, nutritional supplements, and vitamins. Don’t change the dose, start or stop the intake of Alprostadil without your doctor’s notice.


The symptoms of overdose include but are not limited to nausea, dizziness, fainting, pain in the penis, blurred vision, and prolonged erection. If you have taken too much of Alprostadil and have noticed the signs of overdose, call the poison control center or seek immediate medical assistance to avoid complications.


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